Seminars in Ultrasound, CT and MRI
Volume 31, Issue 4 , Pages 321-327 , August 2010

Dual-Energy Derived Virtual Nonenhanced Computed Tomography Imaging: Current Status and Applications

  • Shmuel Mahgerefteh, MD

      Affiliations

    • Department of Radiology, Hadassah Hebrew University Medical Center, Jerusalem, Israel
  • ,
  • Arye Blachar, MD

      Affiliations

    • Department of Radiology, Sourasky Medical Center, Tel Aviv, Israel
  • ,
  • Shifra Fraifeld, MBA

      Affiliations

    • Department of Radiology, Hadassah Hebrew University Medical Center, Jerusalem, Israel
  • ,
  • Jacob Sosna, MD

      Affiliations

    • Department of Radiology, Hadassah Hebrew University Medical Center, Jerusalem, Israel
    • Department of Radiology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA
    • Corresponding Author InformationAddress reprint requests to Jacob Sosna, MD, Department of Radiology, Hadassah Hebrew University Medical Center, POB 12000, Jerusalem, Israel 91120

References 

  1. Maitino AJ, Levin DC, Parker L, et al. Nationwide trends in rates of utilization of noninvasive diagnostic imaging among the Medicare population between 1993 and 1999. Radiology. 2003;227:113–117
  2. Matin A, Bates DW, Sussman A, et al. Inpatient radiology utilization: Trends over the past decade. AJR Am J Roentgenol. 2006;186:7–11
  3. Ionizing Radiation Exposure of the Population of the United States (2009)-Report 160. National Council on Radiation Protection and Measurements. Bethesda, MD: NCRP; 2009;
  4. Mettler FA, Thomadsen BR, Bhargavan M, et al. Medical radiation exposure in the U.S. in 2006: Preliminary results. Health Phys. 2008;95:502–507
  5. Brenner D, Elliston C, Hall E, et al. Estimated risks of radiation-induced fatal cancer from pediatric CT. AJR Am J Roentgenol. 2001;176:289–296
  6. Brenner DJ, Elliston CD. Estimated radiation risks potentially associated with full-body CT screening. Radiology. 2004;232:735–738
  7. de Jong PA, Mayo JR, Golmohammadi K, et al. Estimation of cancer mortality associated with repetitive computed tomography scanning. Am J Respir Crit Care Med. 2006;173:199–203
  8. Catalano C, Francone M, Ascarelli A, et al. Optimizing radiation dose and image quality. Eur Radiol. 2007;17(suppl 6):F26–F32
  9. Fazel R, Krumholz HM, Wang Y, et al. Exposure to low-dose ionizing radiation from medical imaging procedures. N Engl J Med. 2009;361:849–857
  10. Frush DP. Review of radiation issues for computed tomography. Semin Ultrasound CT MR. 2004;25:17–24
  11. Valentin J. Managing patient dose in multi-detector computed tomography (MDCT) 102 (ICRP Publishing Group 102). Ann ICRP. 2007;37:1–79iii
  12. Neumann RD, Bluemke DA. Tracking radiation exposure from diagnostic imaging devices at the NIH. J Am Coll Radiol. 2010;7:87–89
  13. Alvarez RE, Macovski A. Energy-selective reconstructions in X-ray computerized tomography. Phys Med Biol. 1976;21:733–744
  14. Brooks RA. A quantitative theory of the Hounsfield unit and its application to dual energy scanning. J Comput Assist Tomogr. 1977;1:487–493
  15. Johnson TR, Krauss B, Sedlmair M, et al. Material differentiation by dual energy CT: Initial experience. Eur Radiol. 2007;17:1510–1517
  16. Sommer WH, Graser A, Becker CR, et al. Image quality of virtual noncontrast images derived from dual-energy CT angiography after endovascular aneurysm repair. J Vasc Interv Radiol. 2010;21:315–321
  17. Goshen L, Sosna J, Carmi R, et al. An iodine-calcium separation analysis and virtually non-contrasted image generation obtained with single-source dual-energy MDCT, IEEE nuclear science. 2008;Symposium M06-133:3868-3870
  18. Graser A, Johnson TR, Hecht EM, et al. Dual-energy CT in patients suspected of having renal masses: Can virtual nonenhanced images replace true nonenhanced images?. Radiology. 2009;252:433–440
  19. Scheffel H, Stolzmann P, Frauenfelder T, et al. Dual-energy contrast-enhanced computed tomography for the detection of urinary stone disease. Invest Radiol. 2007;42:823–829
  20. Takahashi N, Hartman RP, Vrtiska TJ, et al. Dual-energy CT iodine-subtraction virtual unenhanced technique to detect urinary stones in an iodine-filled collecting system: A phantom study. AJR Am J Roentgenol. 2008;190:1169–1173
  21. Zhang LJ, Peng J, Wu SY, et al. Liver virtual non-enhanced CT with dual-source, dual-energy CT: A preliminary study. Eur Radiol. 2010 Apr 15;(Epub ahead of print)
  22. Chae EJ, Song JW, Seo JB, et al. Clinical utility of dual-energy CT in the evaluation of solitary pulmonary nodules: Initial experience. Radiology. 2008;249:671–681
  23. Chandarana H, Godoy MC, Vlahos I, et al. Abdominal aorta: Evaluation with dual-source dual-energy multidetector CT after endovascular repair of aneurysms—initial observations. Radiology. 2008;249:692–700
  24. Stolzmann P, Frauenfelder T, Pfammatter T, et al. Endoleaks after endovascular abdominal aortic aneurysm repair: Detection with dual-energy dual-source CT. Radiology. 2008;249:682–691
  25. Ferda J, Novak M, Mirka H, et al. The assessment of intracranial bleeding with virtual unenhanced imaging by means of dual-energy CT angiography. Eur Radiol. 2009;19:2518–2522
  26. Israel GM, Bosniak MA. How I do it: Evaluating renal masses. Radiology. 2005;236:441–450
  27. Hoppe H, Studer R, Kessler TM, et al. Alternate or additional findings to stone disease on unenhanced computerized tomography for acute flank pain can impact management. J Urol. 2006;175:1725–1730discussion 1730
  28. McNicholas MM, Raptopoulos VD, Schwartz RK, et al. Excretory phase CT urography for opacification of the urinary collecting system. AJR Am J Roentgenol. 1998;170:1261–1267
  29. Nolte-Ernsting C, Cowan N. Understanding multislice CT urography techniques: Many roads lead to Rome. Eur Radiol. 2006;16:2670–2686
  30. Hamm M, Knopfle E, Wartenberg S, et al. Low dose unenhanced helical computerized tomography for the evaluation of acute flank pain. J Urol. 2002;167:1687–1691
  31. Knopfle E, Hamm M, Wartenberg S, et al. CT in ureterolithiasis with a radiation dose equal to intravenous urography: Results in 209 patients. Rofo. 2003;175:1667–1672
  32. Meagher T, Sukumar VP, Collingwood J, et al. Low dose computed tomography in suspected acute renal colic. Clin Radiol. 2001;56:873–876
  33. Graser A, Johnson TR, Chandarana H, et al. Dual energy CT: Preliminary observations and potential clinical applications in the abdomen. Eur Radiol. 2009;19:13–23
  34. Chow LC, Kwan SW, Olcott EW, et al. Split-bolus MDCT urography with synchronous nephrographic and excretory phase enhancement. AJR Am J Roentgenol. 2007;189:314–322
  35. Federle MP, Blachar A. Evaluation of the liver: principles and techniques. Semin Liver Dis. 2001;21:135–145
  36. Schima W, Ba-Ssalamah A, Kurtaran A, et al. Post-treatment imaging of liver tumours. Cancer Imaging 7 spec No. A. 2007;S28–S36
  37. Jeong YJ, Lee KS, Jeong SY, et al. Solitary pulmonary nodule: characterization with combined wash-in and washout features at dynamic multi-detector row CT. Radiology. 2005;237:675–683
  38. Swensen SJ, Morin RL, Schueler BA, et al. Solitary pulmonary nodule: CT evaluation of enhancement with iodinated contrast material—a preliminary report. Radiology. 1992;182:343–347
  39. Swensen SJ, Viggiano RW, Midthun DE, et al. Lung nodule enhancement at CT: Multicenter study. Radiology. 2000;214:73–80
  40. Chahwan S, Comerota AJ, Pigott JP, et al. Elective treatment of abdominal aortic aneurysm with endovascular or open repair: The first decade. J Vasc Surg. 2007;45:258–262discussion 262
  41. Greenhalgh RM, Brown LC, Kwong GP, et al. Comparison of endovascular aneurysm repair with open repair in patients with abdominal aortic aneurysm (EVAR trial 1), 30-day operative mortality results: Randomised controlled trial. Lancet. 2004;364:843–848
  42. Hynes N, Sultan S. A prospective clinical, economic, and quality-of-life analysis comparing endovascular aneurysm repair (EVAR), open repair, and best medical treatment in high-risk patients with abdominal aortic aneurysms suitable for EVAR: The Irish patient trial. J Endovasc Ther. 2007;14:763–776
  43. Iezzi R, Cotroneo AR, Marano R, et al. Endovascular treatment of thoracic aortic diseases: Follow-up and complications with multi-detector computed tomography angiography. Eur J Radiol. 2008;65:365–376
  44. Zarins CK, White RA, Hodgson KJ, et al. Endoleak as a predictor of outcome after endovascular aneurysm repair: AneuRx multicenter clinical trial. J Vasc Surg. 2000;32:90–107
  45. Brewster DC, Jones JE, Chung TK, et al. Long-term outcomes after endovascular abdominal aortic aneurysm repair: the first decade. Ann Surg. 2006;244:426–438
  46. Macari M, Chandarana H, Schmidt B, et al. Abdominal aortic aneurysm: Can the arterial phase at CT evaluation after endovascular repair be eliminated to reduce radiation dose?. Radiology. 2006;241:908–914
  47. Biller J, Godersky JC, Adams HP. Management of aneurysmal subarachnoid hemorrhage. Stroke. 1988;19:1300–1305
  48. Agid R, Lee SK, Willinsky RA, et al. Acute subarachnoid hemorrhage: Using 64-slice multidetector CT angiography to “triage” patients' treatment. Neuroradiology. 2006;48:787–794
  49. Carmi R, Naveh G, Altman A. Material separation with dual-layer CT. IEEE Nucl Sci Symp Conf Rec. 2005;4:1876–1878

PII: S0887-2171(10)00043-0

doi: 10.1053/j.sult.2010.06.001

Seminars in Ultrasound, CT and MRI
Volume 31, Issue 4 , Pages 321-327 , August 2010