Seminars in Ultrasound, CT and MRI
Volume 29, Issue 1 , Pages 60-70 , February 2008

Predictors, Procedures, and Perspective for Temporal Lobe Epilepsy Surgery

  • Hans Clusmann, MD

      Affiliations

    • Corresponding Author InformationAddress reprint requests to: Hans Clusmann, MD, Neurochirurgische Universitätsklinik Bonn, Sigmund Freud Str. 25, 53105 Bonn, Germany.

References 

  1. Cascino GD. Surgical treatment for epilepsy. Epilepsy Res. 2004;60:179–186
  2. Armon C, Radtke RA, Friedman AH, et al. Predictors of outcome of epilepsy surgery: multivariate analysis with validation. Epilepsia. 1996;37:814–821
  3. Clusmann H, Schramm J, Kral T, et al. Prognostic factors and outcome after different types of resection for temporal lobe epilepsy. J Neurosurg. 2002;97:1131–1141
  4. Foldvary N, Nashold B, Mascha E, et al. Seizure outcome after temporal lobectomy for temporal lobe epilepsy: a Kaplan-Meier survival analysis. Neurology. 2000;54:630–634
  5. Kral T, Clusmann H, Urbach H, et al. Preoperative evaluation for epilepsy surgery (Bonn algorithm). Zentralbl Neurochir. 2002;63:106–110
  6. Olivier A. Relevance of removal of limbic structures in surgery for temporal lobe epilepsy. Can J Neurol Sci. 1991;18:628–635
  7. Radhakrishnan K, So EL, Silbert PL, et al. Predictors of outcome of anterior temporal lobectomy for intractable epilepsy: a multivariate study. Neurology. 1998;51:465–471
  8. Salanova V, Markand O, Worth R. Temporal lobe epilepsy surgery: outcome, complications, and late mortality rate in 215 patients. Epilepsia. 2002;43:170–174
  9. Wiebe S, Blume WT, Girvin JP, et al. A randomized, controlled trial of surgery for temporal-lobe epilepsy. N Engl J Med. 2001;345:311–318
  10. Wieser HG, Yasargil MG. Selective amygdalohippocampectomy as a surgical treatment of mesiobasal limbic epilepsy. Surg Neurol. 1982;17:445–457
  11. Tonini C, Beghi E, Berg AT, et al. Predictors of epilepsy surgery outcome: a meta-analysis. Epilepsy Res. 2004;62:75–87
  12. Engel J, Wiebe S, French J, et al. Practice parameter: temporal lobe and localized neocortical resections for epilepsy: report of the Quality Standards Subcommittee of the American Academy of Neurology, in association with the American Epilepsy Society and the American Association of Neurological Surgeons. Neurology. 2003;60:538–547
  13. Tellez-Zenteno JF, Dhar R, Wiebe S. Long-term seizure outcomes following epilepsy surgery: a systematic review and meta-analysis. Brain. 2005;128:1188–1198
  14. Spencer SS, Berg AT, Vickrey BG, et al. Initial outcomes in the Multicenter Study of Epilepsy Surgery. Neurology. 2003;61:1680–1685
  15. Bertram EH, Williamson JM, Cornett JF, et al. Design and construction of a long-term continuous video-EEG monitoring unit for simultaneous recording of multiple small animals. Brain Res Brain Res Protoc. 1997;2:85–97
  16. Cascino GD. Video-EEG monitoring in adults. Epilepsia. 2002;43:80–93
  17. Elger CE, Hufnagel A, Schramm J. Epilepsy Surgery Protocol University Hospital, Bonn, Germany. In:  Luders HO editors. Epilepsy Surgery. New York, NY: Raven Press; 1992;p. 783–784
  18. Hufnagel A, Dumpelmann M, Zentner J, et al. Clinical relevance of quantified intracranial interictal spike activity in presurgical evaluation of epilepsy. Epilepsia. 2000;41:467–478
  19. Helmstaedter C, Elger CE, Hufnagel A, et al. Different effects of left anterior temporal lobectomy, selective amygdalohippocampectomy, and temporal cortical lesionectomy on verbal learning, memory, and recognition. J Epilepsy. 1996;9:39–45
  20. Helmstaedter C, Grunwald T, Lehnertz K, et al. Differential involvement of left temporolateral and temporomesial structures in verbal declarative learning and memory: evidence from temporal lobe epilepsy. Brain Cogn. 1997;35:110–131
  21. Lutz MT, Clusmann H, Elger CE, et al. Neuropsychological outcome after selective amygdalohippocampectomy with transsylvian versus transcortical approach: a randomized prospective clinical trial of surgery for temporal lobe epilepsy. Epilepsia. 2004;45:809–816
  22. Von Oertzen J, Urbach H, Jungbluth S, et al. Standard magnetic resonance imaging is inadequate for patients with refractory focal epilepsy. J Neurol Neurosurg Psychiatry. 2002;73:643–647
  23. Urbach H, Hattingen J, von Oertzen J, et al. MR imaging in the presurgical workup of patients with drug-resistant epilepsy. AJNR Am J Neuroradiol. 2004;25:919–926
  24. von Oertzen J, Urbach H, Blumcke I, et al. Time-efficient T2 relaxometry of the entire hippocampus is feasible in temporal lobe epilepsy. Neurology. 2002;58:257–264
  25. Siegel AM, Jobst BC, Thadani VM, et al. Medically intractable, localization-related epilepsy with normal MRI: presurgical evaluation and surgical outcome in 43 patients. Epilepsia. 2001;42:883–888
  26. Carne RP, O’Brien TJ, Kilpatrick CJ, et al. MRI-negative PET-positive temporal lobe epilepsy: a distinct surgically remediable syndrome. Brain. 2004;127:2276–2285
  27. Berkovic SF, McIntosh AM, Kalnins RM, et al. Preoperative MRI predicts outcome of temporal lobectomy: an actuarial analysis. Neurology. 1995;45:1358–1363
  28. Scott CA, Fish DR, Smith SJ, et al. Presurgical evaluation of patients with epilepsy and normal MRI: role of scalp video-EEG telemetry. J Neurol Neurosurg Psychiatry. 1999;66:69–71
  29. Holmes MD, Born DE, Kutsy RL, et al. Outcome after surgery in patients with refractory temporal lobe epilepsy and normal MRI. Seizure. 2000;9:407–411
  30. Ho SS, Berkovic SF, Berlangieri SU, et al. Comparison of ictal SPECT and interictal PET in the presurgical evaluation of temporal lobe epilepsy. Ann Neurol. 1995;37:738–745
  31. Radtke RA, Hanson MW, Hoffman JM, et al. Temporal lobe hypometabolism on PET: predictor of seizure control after temporal lobectomy. Neurology. 1993;43:1088–1092
  32. Spencer SS. The relative contributions of MRI, SPECT, and PET imaging in epilepsy. Epilepsia. 1994;35(suppl 6):72–89
  33. Kaiboriboon K, Lowe VJ, Chantarujikapong SI, et al. The usefulness of subtraction ictal SPECT coregistered to MRI in single- and dual-headed SPECT cameras in partial epilepsy. Epilepsia. 2002;43:408–414
  34. O’Brien TJ, So EL, Mullan BP, et al. Subtraction ictal SPECT co-registered to MRI improves clinical usefulness of SPECT in localizing the surgical seizure focus. Neurology. 1998;50:445–454
  35. O’Brien TJ, O’Connor MK, Mullan BP, et al. Subtraction ictal SPET co-registered to MRI in partial epilepsy: description and technical validation of the method with phantom and patient studies. Nucl Med Commun. 1998;19:31–45
  36. Hellstrand E, Abraham-Fuchs K, Jernberg B, et al. MEG localization of interictal epileptic focal activity and concomitant stereotactic radiosurgery (A non-invasive approach for patients with focal epilepsy). Physiol Meas. 1993;14:131–136
  37. Stefan H, Hummel C, Scheler G, et al. Magnetic brain source imaging of focal epileptic activity: a synopsis of 455 cases. Brain. 2003;126:2396–2405
  38. Assaf BA, Karkar KM, Laxer KD, et al. Magnetoencephalography source localization and surgical outcome in temporal lobe epilepsy. Clin Neurophysiol. 2004;115:2066–2076
  39. Fernandez G, de Greiff A, von Oertzen J, et al. Language mapping in less than 15 minutes: real-time functional MRI during routine clinical investigation. Neuroimage. 2001;14:585–594
  40. Killgore WD, Glosser G, Casasanto DJ, et al. Functional MRI and the Wada test provide complementary information for predicting post-operative seizure control. Seizure. 1999;8:450–455
  41. Richardson MP, Strange BA, Thompson PJ, et al. Pre-operative verbal memory fMRI predicts post-operative memory decline after left temporal lobe resection. Brain. 2004;127:2419–2426
  42. Szaflarski JP, Holland SK, Schmithorst VJ, et al. High-resolution functional MRI at 3T in healthy and epilepsy subjects: hippocampal activation with picture encoding task. Epilepsy Behav. 2004;5:244–252
  43. Behrens E, Zentner J, Van Roost D, et al. Subdural and depth electrodes in the presurgical evaluation of epilepsy. Acta Neurochir. 1994;128:84–87
  44. Spencer SS, Spencer DD, Williamson PD, et al. Combined depth and subdural electrode investigation in uncontrolled epilepsy. Neurology. 1990;40:74–79
  45. Spencer SS, Spencer DD, Williamson PD, et al. The localizing value of depth electroencephalography in 32 patients with refractory epilepsy. Ann Neurol. 1982;12:248–253
  46. Van Roost D, Solymosi L, Schramm J, et al. Depth electrode implantation in the length axis of the hippocampus for the presurgical evaluation of medial temporal lobe epilepsy: a computed tomography-based stereotactic insertion technique and its accuracy. Neurosurgery. 1998;43:819–826
  47. Fernandez G, Hufnagel A, Van Roost D, et al. Safety of intrahippocampal depth electrodes for presurgical evaluation of patients with intractable epilepsy. Epilepsia. 1997;38:922–929
  48. Lee WS, Lee JK, Lee SA, et al. Complications and results of subdural grid electrode implantation in epilepsy surgery. Surg Neurol. 2000;54:346–351
  49. Murphy MA, O’Brien TJ, Cook MJ. Insertion of depth electrodes with or without subdural grids using frameless stereotactic guidance systems—technique and outcome. Br J Neurosurg. 2002;16:119–125
  50. Mahvash M, Konig R, Urbach H, et al. FLAIR-/T1-/T2-co-registration for image-guided diagnostic and resective epilepsy surgery. Neurosurgery. 2006;58:ONS-69-ONS-75
  51. Wellmer J, von Oertzen J, Schaller C, et al. Digital photography and 3D MRI-based multimodal imaging for individualized planning of resective neocortical epilepsy surgery. Epilepsia. 2002;43:1543–1550
  52. Stefan H, Pauli E, Eberhard F, et al. [“Tailoring” resections in drug refractory temporal lobe epilepsy]. Nervenarzt. 1996;67:306–310
  53. McKhann GM, Schoenfeld-McNeill J, Born DE, et al. Intraoperative hippocampal electrocorticography to predict the extent of hippocampal resection in temporal lobe epilepsy surgery. J Neurosurg. 2000;93:44–52
  54. Arruda F, Cendes F, Andermann F, et al. Mesial atrophy and outcome after amygdalohippocampectomy or temporal lobe removal. Ann Neurol. 1996;40:446–450
  55. Clusmann H, Kral T, Gleissner U, et al. Analysis of different types of resection for pediatric patients with temporal lobe epilepsy. Neurosurgery. 2004;54:1–13
  56. Mohamed A, Wyllie E, Ruggieri P, et al. Temporal lobe epilepsy due to hippocampal sclerosis in pediatric candidates for epilepsy surgery. Neurology. 2001;56:1643–1649
  57. Salanova V, Markand O, Worth R, et al. Presurgical evaluation and surgical outcome of temporal lobe epilepsy. Pediatr Neurol. 1999;20:179–184
  58. Gleissner U, Sassen R, Lendt M, et al. Pre- and postoperative verbal memory in pediatric patients with temporal lobe epilepsy. Epilepsy Res. 2002;51:287–296
  59. Westerveld M, Sass KJ, Chelune GJ, et al. Temporal lobectomy in children: cognitive outcome. J Neurosurg. 2000;92:24–30
  60. Engel J, Van Ness P, Rasmussen TB, et al. Outcome with respect to epileptic seizures. In:  Engel J editors. Surgical Treatment of the Epilepsies. (ed 2). New York, NY: Raven Press Ltd; 1993;p. 609–621
  61. Wieser HG, Ortega M, Friedman A, et al. Long-term seizure outcomes following amygdalohippocampectomy. J Neurosurg. 2003;98:751–763
  62. Wieser HG, Blume WT, Fish D, et al. ILAE Commission Report (Proposal for a new classification of outcome with respect to epileptic seizures following epilepsy surgery). Epilepsia. 2001;42:282–286
  63. Olivier A. Transcortical selective amygdalohippocampectomy in temporal lobe epilepsy. Can J Neurol Sci. 2000;27(suppl 1):68–76
  64. Yasargil MG, Teddy PJ, Roth P. Selective amygdalo-hippocampectomy (Operative anatomy and surgical technique). Adv Tech Stand Neurosurg. 1985;12:93–123
  65. Spencer DD, Spencer SS, Mattson RH, et al. Access to the posterior medial temporal lobe structures in the surgical treatment of temporal lobe epilepsy. Neurosurgery. 1984;15:667–671
  66. Renowden SA, Matkovic Z, Adams CB, et al. Selective amygdalohippocampectomy for hippocampal sclerosis: postoperative MR appearance. AJNR Am J Neuroradiol. 1995;16:1855–1861
  67. Nayel MH, Awad IA, Luders H. Extent of mesiobasal resection determines outcome after temporal lobectomy for intractable complex partial seizures. Neurosurgery. 1991;29:55–60
  68. Awad IA, Katz A, Hahn JF, et al. Extent of resection in temporal lobectomy for epilepsy. I (Interobserver analysis and correlation with seizure outcome). Epilepsia. 1989;30:756–762
  69. Bonilha L, Kobayashi E, Mattos JP, et al. Value of extent of hippocampal resection in the surgical treatment of temporal lobe epilepsy. Ar Qneuropsiquiatr. 2004;62:15–20
  70. Wyler AR, Hermann BP, Somes G. Extent of medial temporal resection on outcome from anterior temporal lobectomy: a randomized prospective study. Neurosurgery. 1995;37:982–990
  71. Wyler AR, Hermann BP, Richey ET. Results of reoperation for failed epilepsy surgery. J Neurosurg. 1989;71:815–819
  72. Awad IA, Nayel MH, Luders H. Second operation after the failure of previous resection for epilepsy. Neurosurgery. 1991;28:510–518
  73. Germano IM, Poulin N, Olivier A. Reoperation for recurrent temporal lobe epilepsy. J Neurosurg. 1994;81:31–36
  74. Hennessy MJ, Elwes RD, Binnie CD, et al. Failed surgery for epilepsy: A study of persistence and recurrence of seizures following temporal resection. Brain. 2000;123:2445–2466
  75. Hennessy MJ, Elwes RD, Rabe-Hesketh S, et al. Prognostic factors in the surgical treatment of medically intractable epilepsy associated with mesial temporal sclerosis. Acta Neurol Scand. 2001;103:344–350
  76. Ho SS, Berkovic SF, McKay WJ, et al. Temporal lobe epilepsy subtypes: differential patterns of cerebral perfusion on ictal SPECT. Epilepsia. 1996;37:788–795
  77. Hamer HM, Najm I, Mohamed A, et al. Interictal epileptiform discharges in temporal lobe epilepsy due to hippocampal sclerosis versus medial temporal lobe tumors. Epilepsia. 1999;40:1261–1268
  78. Clusmann H, Kral T, Fackeldey E, et al. Lesional mesial temporal lobe epilepsy and limited resections—prognostic factors and outcome. J Neurol Neurosurg Psychiatry. 2004;75:1589–1596
  79. Schramm J, Kral T, Grunwald T, et al. Surgical treatment for neocortical temporal lobe epilepsy: clinical and surgical aspects and seizure outcome. J Neurosurg. 2001;94:33–42
  80. Egan RA, Shults WT, So N, et al. Visual field deficits in conventional anterior temporal lobectomy versus amygdalohippocampectomy. Neurology. 2000;55:1818–1822
  81. Katz A, Awad IA, Kong AK, et al. Extent of resection in temporal lobectomy for epilepsy. II (Memory changes and neurologic complications). Epilepsia. 1989;30:763–771
  82. Yasargil MG, Vise WM, Bader DC. Technical adjuncts in neurosurgery. Surg Neurol. 1977;8:331–336
  83. Pilcher W, Roberts D, Flanigin HF, et al. Complications of epilepsy surgery. In:  Engel J editors. Surgical Treatment of the Epilepsies. (ed 2). New York, NY: Raven Press; 1993;p. 565–581
  84. Polkey C. Complications of epilepsy surgery. In:  Shorvon SD,  Dreifuss F,  Fish D, et al. editor. The Treatment of Epilepsy. Oxford: Blackwell Science Ltd; 1996;p. 780–793
  85. Kalfas IH, Little JR. Postoperative hemorrhage: a survey of 4992 intracranial procedures. Neurosurgery. 1988;23:343–347
  86. Palmer JD, Sparrow OC, Iannotti F. Postoperative hematoma: a 5-year survey and identification of avoidable risk factors. Neurosurgery. 1994;35:1061–1064
  87. Gil-Fernandez JJ. Analysis of surgical blood loss and number of blood transfusions after temporal lobe resection performed in adults with epilepsy receiving valproate (VPA) in the immediate preoperative period. Epilepsia. 1997;38:1257–1258
  88. Behrens E, Schramm J, Zentner J, et al. Surgical and neurological complications in a series of 708 epilepsy surgery procedures. Neurosurgery. 1997;41:1–9
  89. Grivas A, Schramm J, Kral T, et al. Surgical treatment for refractory temporal lobe epilepsy in the elderly—seizure outcome and neuropsychological sequels compared to a younger cohort. Epilepsia. 2006;47:1364–1372
  90. Clusmann H, Kral T, Marin G, et al. Characterization of hemorrhagic complications after surgery for temporal lobe epilepsy. Zentralbl Neurochir. 2004;65:128–134
  91. Honnegger J, Zentner J, Spreer J, et al. Cerebellar hemorrhage arising postoperatively as a complication of supratentorial surgery: a retrospective study. J Neurosurg. 2002;96:248–254
  92. Helmstaedter C, Van Roost D, Clusmann H, et al. Collateral brain damage, a potential source of cognitive impairment after selective surgery for control of mesial temporal lobe epilepsy. J Neurol Neurosurg Psychiatry. 2004;75:323–326
  93. Hermann BP, Wyler AR, Bush AJ, et al. Differential effects of left and right anterior temporal lobectomy on verbal learning and memory performance. Epilepsia. 1992;33:289–297
  94. Helmstaedter C, Elger CE. Cognitive consequences of two-thirds anterior temporal lobectomy on verbal memory in 144 patients: a three-month follow-up study. Epilepsia. 1996;37:171–180
  95. Gleissner U, Helmstaedter C, Schramm J, et al. Memory outcome after selective amygdalohippocampectomy: a study in 140 patients with temporal lobe epilepsy. Epilepsia. 2002;43:87–95
  96. Gleissner U, Helmstaedter C, Schramm J, et al. Memory outcome after selective amygdalohippocampectomy in patients with temporal lobe epilepsy: one-year follow-up. Epilepsia. 2004;45:960–962
  97. Gleissner U, Helmstaedter C, Elger CE. Right hippocampal contribution to visual memory: a presurgical and postsurgical study in patients with temporal lobe epilepsy. J Neurol Neurosurg Psychiatry. 1998;65:665–669
  98. Goldstein LH, Polkey CE. Short-term cognitive changes after unilateral temporal lobectomy or unilateral amygdalo-hippocampectomy for the relief of temporal lobe epilepsy. J Neurol Neurosurg Psychiatry. 1993;56:135–140
  99. Rasmussen T, Jasper HH. Temporal lobe epilepsy: indications for operation and surgical technique. In:  Baldwin M,  Bailey P editor. Temporal Lobe Epilepsy. Springfield, IL: Charles C. Thomas; 1958;p. 440–460
  100. McLachlan RS, Rose KJ, Derry PA, et al. Health-related quality of life and seizure control in temporal lobe epilepsy. Ann Neurol. 1997;41:482–489
  101. Vickrey BG, Hays RD, Engel J, et al. Outcome assessment for epilepsy surgery: the impact of measuring health-related quality of life. Ann Neurol. 1995;37:158–166
  102. von Lehe M, Lutz MT, Kral T, et al. Correlation of health related quality of life after surgery for mesial temporal lobe epilepsy with two different seizure outcome scales. Epilepsy Behav. 2006;9:73–82
  103. Bengzon AR, Rasmussen T, Gloor P, et al. Prognostic factors in the surgical treatment of temporal lobe epileptics. Neurology. 1968;18:717–731
  104. Gilliam F, Faught E, Martin R, et al. Predictive value of MRI-identified mesial temporal sclerosis for surgical outcome in temporal lobe epilepsy: an intent-to-treat analysis. Epilepsia. 2000;41:963–966
  105. Guldvog B, Loyning Y, Hauglie-Hanssen E, et al. Predictive factors for success in surgical treatment for partial epilepsy: a multivariate analysis. Epilepsia. 1994;35:566–578
  106. Jeong SW, Lee SK, Kim KK, et al. Prognostic factors in anterior temporal lobe resections for mesial temporal lobe epilepsy: multivariate analysis. Epilepsia. 1999;40:1735–1739
  107. Sylaja PN, Radhakrishnan K, Kesavadas C, et al. Seizure outcome after anterior temporal lobectomy and its predictors in patients with apparent temporal lobe epilepsy and normal MRI. Epilepsia. 2004;45:803–808
  108. Altshuler L, Rausch R, Delrahim S, et al. Temporal lobe epilepsy, temporal lobectomy, and major depression. J Neuropsychiatry Clin Neurosci. 1999;11:436–443
  109. Bladin PF. Psychosocial difficulties and outcome after temporal lobectomy. Epilepsia. 1992;33:898–907
  110. Reuber M, Andersen B, Elger CE, et al. Depression and anxiety before and after temporal lobe epilepsy surgery. Seizure. 2004;13:129–135
  111. Blatt DR, Roper SN, Friedman WA. Invasive monitoring of limbic epilepsy using stereotactic depth and subdural strip electrodes: surgical technique. Surg Neurol. 1997;48:74–79
  112. Cascino GD, Trenerry MR, Sharbrough FW, et al. Depth electrode studies in temporal lobe epilepsy: relation to quantitative magnetic resonance imaging and operative outcome. Epilepsia. 1995;36:230–235
  113. Luders H, Awad I, Burgess R, et al. Subdural electrodes in the presurgical evaluation for surgery of epilepsy. Epilepsy Res Suppl. 1992;5:147–156
  114. Helmstaedter C. Neuropsychological aspects of epilepsy surgery. Epilepsy Behav. 2004;5(suppl 1):S45–S55
  115. Jones-Gotman M, Harnadek MC, Kubu CS. Neuropsychological assessment for temporal lobe epilepsy surgery. Can J Neurol Sci. 2000;27(suppl 1):39–43
  116. Kim H, Yi S, Son EI, et al. Lateralization of epileptic foci by neuropsychological testing in mesial temporal lobe epilepsy. Neuropsychology. 2004;18:141–151
  117. Schramm J, Aliashkevich AF, Grunwald T. Multiple subpial transections: outcome and complications in 20 patients who did not undergo resection. J Neurosurg. 2002;97:39–47
  118. Aydemir N, Ozkara C, Canbeyli R, et al. Changes in quality of life and self-perspective related to surgery in patients with temporal lobe epilepsy. Epilepsy Behav. 2004;5:735–742
  119. Gilliam F. The impact of epilepsy on subjective health status. Curr Neurol Neurosci Rep. 2003;3:357–362
  120. Sutherland GR, Kaibara T, Louw DF. Intraoperative MR at 1.5 Tesla—experience and future directions. Acta Neurochir Suppl. 2003;85:21–28
  121. Janszky J, Ollech I, Jokeit H, et al. Epileptic activity influences the lateralization of mesiotemporal fMRI activity. Neurology. 2004;63:1813–1817
  122. Kier EL, Staib LH, Davis LM, et al. MR imaging of the temporal stem: anatomic dissection tractography of the uncinate fasciculus, inferior occipitofrontal fasciculus, and Meyer’s loop of the optic radiation. AJNR Am J Neuroradiol. 2004;25:677–691
  123. Janszky J, Jokeit H, Kontopoulou K, et al. Functional MRI predicts memory performance after right mesiotemporal epilepsy surgery. Epilepsia. 2005;46:244–250
  124. Krakow K, Lemieux L, Messina D, et al. Spatio-temporal imaging of focal interictal epileptiform activity using EEG-triggered functional MRI. Epileptic Disord. 2001;3:67–74
  125. Lemieux L, Salek-Haddadi A, Josephs O, et al. Event-related fMRI with simultaneous and continuous EEG: description of the method and initial case report. Neuroimage. 2001;14:780–787
  126. Liston AD, Salek-Haddadi A, Kiebel SJ, et al. The MR detection of neuronal depolarization during 3-Hz spike-and-wave complexes in generalized epilepsy. Magn Reson Imaging. 2004;22:1441–1444
  127. Lemieux L. Electroencephalography-correlated functional MR imaging studies of epileptic activity. Neuroimaging Clin North Am. 2004;14:487–506
  128. Engel J. Multimodal approaches in the evaluation of epilepsy patients for surgery. Electroencephalogr Clin Neurophysiol Suppl. 1999;50:40–52
  129. Van Roost D, Schaller C, Meyer B, et al. Can neuronavigation contribute to standardization of selective amygdalohippocampectomy?. Stereotact Funct Neurosurg. 1997;69:239–242
  130. Regis J, Rey M, Bartolomei F, et al. Gamma knife surgery in mesial temporal lobe epilepsy: a prospective multicenter study. Epilepsia. 2004;45:504–515
  131. Parrent AG, Blume WT. Stereotactic amygdalohippocampotomy for the treatment of medial temporal lobe epilepsy. Epilepsia. 1999;40:1408–1416
  132. Guenot M, Isnard J, Ryvlin P, et al. SEEG-guided RF thermocoagulation of epileptic foci: feasibility, safety, and preliminary results. Epilepsia. 2004;45:1368–1374
  133. Vonck K, Boon P, Goossens L, et al. Neurostimulation for refractory epilepsy. Acta Neurol Belg. 2003;103:213–217

 This work was supported in part by a grant of the Deutsche Gesellschaft für Neurochirurgie, Stiftung Neurochirurgische Forschung to H.C.

PII: S0887-2171(07)00100-X

doi: 10.1053/j.sult.2007.11.004

Seminars in Ultrasound, CT and MRI
Volume 29, Issue 1 , Pages 60-70 , February 2008

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