Seminars in Ultrasound, CT and MRI
Volume 28, Issue 6 , Pages 424-436 , December 2007

MR Imaging of Temporal Lobe Epilepsy

  • Daniel L.A. Camacho, MD, PhD

      Affiliations

    • Radiology Associates of the Fox Valley, Neenah, WI.
  • ,
  • Mauricio Castillo, MD

      Affiliations

    • Department of Radiology, University of North Carolina, Chapel Hill, NC.
    • Corresponding Author InformationAddress reprint requests to: Mauricio Castillo, MD, CB #7510, Radiology, UNC-CH, Chapel Hill, NC 27599.

References 

  1. Bell GS, Sander JW. The epidemiology of epilepsy: the size of the problem. Seizure. 2001;10(4):306–314quiz 315-316
  2. Fisher RS, Stein A, Karis J. Epilepsy for the neuroradiologist. AJNR Am J Neuroradiol. 1997;18(5):851–863
  3. Bronen RA, Fulbright RK, Kim JH, Spencer SS, Spencer DD. A systematic approach for interpreting MR images of the seizure patient. AJR Am J Roentgenol. 1997;169(1):241–247
  4. Van Paesschen W. Qualitative and quantitative imaging of the hippocampus in mesial temporal lobe epilepsy with hippocampal sclerosis. Neuroimaging Clin N Am. 2004;14(3):373–400vii
  5. Spencer SS. When should temporal-lobe epilepsy be treated surgically?. Lancet Neurol. 2002;1(6):375–382
  6. McBride MC, Bronstein KS, Bennett B, Erba G, Pilcher W, Berg MJ. Failure of standard magnetic resonance imaging in patients with refractory temporal lobe epilepsy. Arch Neurol. 1998;55(3):346–348
  7. Von Oertzen J, Urbach H, Jungbluth S, Kurthen M, Reuber M, Fernandez G, et al. Standard magnetic resonance imaging is inadequate for patients with refractory focal epilepsy. J Neurol Neurosurg Psychiatry. 2002;73(6):643–647
  8. Lee DH, Gao FQ, Rogers JM, Gulka I, Mackenzie IR, Parrent AG, et al. MR in temporal lobe epilepsy: analysis with pathologic confirmation. AJNR Am J Neuroradiol. 1998;19(1):19–27
  9. Grattan-Smith JD, Harvey AS, Desmond PM, Chow CW. Hippocampal sclerosis in children with intractable temporal lobe epilepsy: detection with MR imaging. AJR Am J Roentgenol. 1993;161(5):1045–1048
  10. Cheon JE, Chang KH, Kim HD, Han MH, Hong SH, Seong SO, et al. MR of hippocampal sclerosis: comparison of qualitative and quantitative assessments. AJNR Am J Neuroradiol. 1998;19(3):465–468
  11. Meiners LC, van Gils AD, De Kort G, Van Der Graaf Y, Jansen GH, Van Veelen CW. Fast fluid-attenuated inversion recovery (FLAIR) compared with T2-weighted spin-echo in the magnetic resonance diagnosis of mesial temporal sclerosis. Invest Radiol. 1999;34(2):134–142
  12. Mitchell LA, Jackson GD, Kalnins RM, Saling MM, Fitt GJ, Ashpole RD, et al. Anterior temporal abnormality in temporal lobe epilepsy: a quantitative MRI and histopathologic study. Neurology. 1999;52(2):327–336
  13. Baldwin GN, Tsuruda JS, Maravilla KR, Hamill GS, Hayes CE. The fornix in patients with seizures caused by unilateral hippocampal sclerosis: detection of unilateral volume loss on MR images. AJR Am J Roentgenol. 1994;162(5):1185–1189
  14. Meiners LC, van Gils A, Jansen GH, de Kort G, Witkamp TD, Ramos LM, et al. Temporal lobe epilepsy: the various MR appearances of histologically proven mesial temporal sclerosis. AJNR Am J Neuroradiol. 1994;15(8):1547–1555
  15. Castillo M. Neuroradiology (The Core Curriculum). Philadelphia: Lippincott Williams and Wilkins; 2002;
  16. Jackson GD. The diagnosis of hippocampal sclerosis: other techniques. Magn Reson Imaging. 1995;13(8):1081–1093
  17. Pell GS, Briellmann RS, Waites AB, Abbott DF, Jackson GD. Voxel-based relaxometry: a new approach for analysis of T2 relaxometry changes in epilepsy. Neuroimage. 2004;21(2):707–713
  18. Duncan JS, Bartlett P, Barker GJ. Technique for measuring hippocampal T2 relaxation time. AJNR Am J Neuroradiol. 1996;17(10):1805–1810
  19. Van Paesschen W, Sisodiya S, Connelly A, Duncan JS, Free SL, Raymond AA, et al. Quantitative hippocampal MRI and intractable temporal lobe epilepsy. Neurology. 1995;45(12):2233–2240
  20. Namer IJ, Waydelich R, Armspach JP, Hirsch E, Marescaux C, Grucker D. Contribution of T2 relaxation time mapping in the evaluation of cryptogenic temporal lobe epilepsy. Neuroimage. 1998;7(4 pt 1):304-133
  21. Bernasconi A, Bernasconi N, Caramanos Z, Reutens DC, Andermann F, Dubeau F, et al. T2 relaxometry can lateralize mesial temporal lobe epilepsy in patients with normal MRI. Neuroimage. 2000;12(6):739–746
  22. Townsend TN, Bernasconi N, Pike GB, Bernasconi A. Quantitative analysis of temporal lobe white matter T2 relaxation time in temporal lobe epilepsy. Neuroimage. 2004;23(1):318–324
  23. Hogan RE, Wang L, Bertrand ME, Willmore LJ, Bucholz RD, Nassif AS, et al. MRI-based high-dimensional hippocampal mapping in mesial temporal lobe epilepsy. Brain. 2004;127(pt 8):1731–1740
  24. Kaiboriboon K, Hogan RE. Hippocampal shape analysis in status epilepticus associated with acute encephalitis. AJNR Am J Neuroradiol. 2002;23(6):1003–1006
  25. Hogan RE, Mark KE, Wang L, Joshi S, Miller MI, Bucholz RD. Mesial temporal sclerosis and temporal lobe epilepsy: MR imaging deformation-based segmentation of the hippocampus in five patients. Radiology. 2000;216(1):291–297
  26. Lencz T, McCarthy G, Bronen RA, Scott TM, Inserni JA, Sass KJ, et al. Quantitative magnetic resonance imaging in temporal lobe epilepsy: relationship to neuropathology and neuropsychological function. Ann Neurol. 1992;31(6):629–637
  27. Cascino GD, Trenerry MR, Jack CR, Dodick D, Sharbrough FW, So EL, et al. Electrocorticography and temporal lobe epilepsy: relationship to quantitative MRI and operative outcome. Epilepsia. 1995;36(7):692–696
  28. Jack CR, Sharbrough FW, Cascino GD, Hirschorn KA, O’Brien PC, Marsh WR. Magnetic resonance image-based hippocampal volumetry: correlation with outcome after temporal lobectomy. Ann Neurol. 1992;31(2):138–146
  29. Mackay CE, Webb JA, Eldridge PR, Chadwick DW, Whitehouse GH, Roberts N. Quantitative magnetic resonance imaging in consecutive patients evaluated for surgical treatment of temporal lobe epilepsy. Magn Reson Imaging. 2000;18(10):1187–1199
  30. Kuzniecky R, Palmer C, Hugg J, Martin R, Sawrie S, et al. Magnetic resonance spectroscopic imaging in temporal lobe epilepsy: neuronal dysfunction or cell loss?. Arch Neurol. 2001;58(12):2048–2053
  31. Thompson JE, Castillo M, Kwock L, Walters B, Beach R. Usefulness of proton MR spectroscopy in the evaluation of temporal lobe epilepsy. AJR Am J Roentgenol. 1998;170(3):771–776
  32. Achten E, Santens P, Boon P, De Coo D, Van De Kerckhove T, De Reuck J, et al. Single-voxel proton MR spectroscopy and positron emission tomography for lateralization of refractory temporal lobe epilepsy. AJNR Am J Neuroradiol. 1998;19(1):1–8
  33. Kantarci K, Shin C, Britton JW, So EL, Cascino GD, Jack CR. Comparative diagnostic utility of 1H MRS and DWI in evaluation of temporal lobe epilepsy. Neurology. 2002;58(12):1745–1753
  34. Park SW, Chang KH, Kim HD, Song IC, Lee DS, Lee SK, et al. Lateralizing ability of single-voxel proton mr spectroscopy in hippocampal sclerosis: comparison with mr imaging and positron emission tomography. AJNR Am J Neuroradiol. 2001;22(4):625–631
  35. Kuzniecky R, Hugg JW, Hetherington H, Butterworth E, Bilir E, Faught E, et al. Relative utility of 1H spectroscopic imaging and hippocampal volumetry in the lateralization of mesial temporal lobe epilepsy. Neurology. 1998;51(1):66–71
  36. Duzel E, Kaufmann J, Guderian S, Szentkuti A, Schott B, Bodammer N, et al. Measures of hippocampal volumes, diffusion and 1H MRS metabolic abnormalities in temporal lobe epilepsy provide partially complementary information. Eur J Neurol. 2004;11(3):195–205
  37. Cendes F, Caramanos Z, Andermann F, Dubeau F, Arnold DL. Proton magnetic resonance spectroscopic imaging and magnetic resonance imaging volumetry in the lateralization of temporal lobe epilepsy: a series of 100 patients. Ann Neurol. 1997;42(5):737–746
  38. Vermathen P, Laxer KD, Matson GB, Weiner MW. Hippocampal structures: anteroposterior N-acetylaspartate differences in patients with epilepsy and control subjects as shown with proton MR spectroscopic imaging. Radiology. 2000;214(2):403–410
  39. Vermathen P, Laxer KD, Schuff N, Matson GB, Weiner MW. Evidence of neuronal injury outside the medial temporal lobe in temporal lobe epilepsy: N-acetylaspartate concentration reductions detected with multisection proton MR spectroscopic imaging–initial experience. Radiology. 2003;226(1):195–202
  40. Capizzano AA, Vermathen P, Laxer KD, Ende GR, Norman D, Rowley H, et al. Temporal lobe epilepsy: qualitative reading of 1H MR spectroscopic images for presurgical evaluation. Radiology. 2001;218(1):144–151
  41. Capizzano AA, Vermathen P, Laxer KD, Matson GB, Maudsley AA, Soher BJ, et al. Multisection proton MR spectroscopy for mesial temporal lobe epilepsy. AJNR Am J Neuroradiol. 2002;23(8):1359–1368
  42. Meiners LC, van der Grond J, van Rijen PC, Springorum R, de Kort GA, Jansen GH. Proton magnetic resonance spectroscopy of temporal lobe white matter in patients with histologically proven hippocampal sclerosis. J Magn Reson Imaging. 2000;11(1):25–31
  43. Wellard RM, Briellmann RS, Prichard JW, Syngeniotis A, Jackson GD. Myoinositol abnormalities in temporal lobe epilepsy. Epilepsia. 2003;44(6):815–821
  44. Castillo M, Smith JK, Kwock L. Proton MR spectroscopy in patients with acute temporal lobe seizures. AJNR Am J Neuroradiol. 2001;22(1):152–157
  45. Lev MH, Rosen BR. Clinical applications of intracranial perfusion MR imaging. Neuroimaging Clin N Am. 1999;9(2):309–331
  46. Szabo K, Poepel A, Pohlmann-Eden B, Hirsch J, Back T, Sedlaczek O, et al. Diffusion-weighted and perfusion MRI demonstrates parenchymal changes in complex partial status epilepticus. Brain. 2005;128(pt 6):1369–1376
  47. Wu RH, Bruening R, Noachtar S, Arnold S, Berchtenbreiter C, Bartenstein P, et al. MR measurement of regional relative cerebral blood volume in epilepsy. J Magn Reson Imaging. 1999;9(3):435–440
  48. Wolf RL, Alsop DC, Levy-Reis I, Meyer PT, Maldjian JA, Gonzalez-Atavales J, et al. Detection of mesial temporal lobe hypoperfusion in patients with temporal lobe epilepsy by use of arterial spin labeled perfusion MR imaging. AJNR Am J Neuroradiol. 2001;22(7):1334–1341
  49. Warach S, Levin JM, Schomer DL, Holman BL, Edelman RR. Hyperperfusion of ictal seizure focus demonstrated by MR perfusion imaging. AJNR Am J Neuroradiol. 1994;15(5):965–968
  50. Wieshmann UC, Clark CA, Symms MR, Barker GJ, Birnie KD, Shorvon SD. Water diffusion in the human hippocampus in epilepsy. Magn Reson Imaging. 1999;17(1):29–36
  51. Hugg JW, Butterworth EJ, Kuzniecky RI. Diffusion mapping applied to mesial temporal lobe epilepsy: preliminary observations. Neurology. 1999;53(1):173–176
  52. Londono A, Castillo M, Lee YZ, Smith JK. Apparent diffusion coefficient measurements in the hippocampi in patients with temporal lobe seizures. AJNR Am J Neuroradiol. 2003;24(8):1582–1586
  53. Konermann S, Marks S, Ludwig T, Weber J, de Greiff A, Dorfler A, et al. Presurgical evaluation of epilepsy by brain diffusion: MR-detected effects of flumazenil on the epileptogenic focus. Epilepsia. 2003;44(3):399–407
  54. Yoo SY, Chang KH, Song IC, Han MH, Kwon BJ, Lee SH, et al. Apparent diffusion coefficient value of the hippocampus in patients with hippocampal sclerosis and in healthy volunteers. AJNR Am J Neuroradiol. 2002;23(5):809–812
  55. Oh JB, Lee SK, Kim KK, Song IC, Chang KH. Role of immediate postictal diffusion-weighted MRI in localizing epileptogenic foci of mesial temporal lobe epilepsy and non-lesional neocortical epilepsy. Seizure. 2004;13(7):509–516
  56. Diehl B, Najm I, Ruggieri P, Tkach J, Mohamed A, Morris H, et al. Postictal diffusion-weighted imaging for the localization of focal epileptic areas in temporal lobe epilepsy. Epilepsia. 2001;42(1):21–28
  57. Lansberg MG, O’Brien MW, Norbash AM, Moseley ME, Morrell M, Albers GW. MRI abnormalities associated with partial status epilepticus. Neurology. 1999;52(5):1021–1027
  58. Hufnagel A, Weber J, Marks S, Ludwig T, De Greiff A, Leonhardt G, et al. Brain diffusion after single seizures. Epilepsia. 2003;44(1):54–63
  59. Meiners LC, Valk J, Jansen GH, van Veelen CW. MR contribution in surgery of epilepsy. Eur Radiol. 1999;9(3):493–507
  60. van Veelen CW, Debets RM, van Huffelen AC, van Emde Boas W, Binnie CD, Storm van Leeuwen W, et al. Combined use of subdural and intracerebral electrodes in preoperative evaluation of epilepsy. Neurosurgery. 1990;26(1):93–101
  61. Schwartz TH, Marks D, Pak J, Hill J, Mandelbaum DE, Holodny AI, et al. Standardization of amygdalohippocampectomy with intraoperative magnetic resonance imaging: preliminary experience. Epilepsia. 2002;43(4):430–436
  62. Smith JR, King DW, Park YD, Lee MR, Lee GP, Jenkins PD. Magnetic source imaging guidance of gamma knife radiosurgery for the treatment of epilepsy. J Neurosurg. 2000;93(suppl 3):136–140
  63. Moran NF, Lemieux L, Maudgil D, Kitchen ND, Fish DR, Shorvon SD. Analysis of temporal lobe resections in MR images. Epilepsia. 1999;40(8):1077–1084
  64. Hajek M, Dezortova M, Liscak R, Vymazal J, Vladyka V. 1H MR spectroscopy of mesial temporal lobe epilepsies treated with Gamma knife. Eur Radiol. 2003;13(5):994–1000
  65. Serles W, Li LM, Antel SB, Cendes F, Gotman J, Olivier A, et al. Time course of postoperative recovery of N-acetyl-aspartate in temporal lobe epilepsy. Epilepsia. 2001;42(2):190–197
  66. Barkovich AJ, Rowley HA, Andermann F. MR in partial epilepsy: value of high-resolution volumetric techniques. AJNR Am J Neuroradiol. 1995;16(2):339–343
  67. Vattipally VR, Bronen RA. MR imaging of epilepsy: strategies for successful interpretation. Neuroimaging Clin N Am. 2004;14(3):349–372
  68. Bronen RA, Fulbright RK, Spencer DD, Spencer SS, Kim JH, Lange RC. MR characteristics of neoplasms and vascular malformations associated with epilepsy. Magn Reson Imaging. 1995;13(8):1153–1162

PII: S0887-2171(07)00077-7

doi: 10.1053/j.sult.2007.09.005

Seminars in Ultrasound, CT and MRI
Volume 28, Issue 6 , Pages 424-436 , December 2007