Seminars in Ultrasound, CT and MRI
Volume 27, Issue 2 , Pages 111-116 , April 2006

Drug-Induced Lung Diseases: Most Common Reaction Patterns and Corresponding High-Resolution CT Manifestations

  • C. Isabela
  • ,
  • S. Silva, MD, PhD
  • ,
  • Nestor L. Müller, MD, PhD

      Affiliations

    • Corresponding Author InformationAddress reprint requests to Dr. Nestor L. Müller, Department of Radiology, Vancouver General Hospital, 899 W. 12th Avenue, Vancouver, BC, Canada V5Z 1M9; Phone: 604-875-4165; Fax: 604-875-4723

References 

  1. Zitnik RJ , Cooper JA . Pulmonary disease due to antirheumatic agents . Clin Chest Med . 1990;11:139–150
  2. Akira M , Ishikawa H , Yamamoto S . Drug-induced pneumonitis (Thin-section CT findings in 60 patients) . Radiology . 2002;224:852–860
  3. Rosenow EC , Limper AH . Drug-induced pulmonary disease . Semin Respir Infect . 1995;10:86–95
  4. Cleverley JR , Screaton NJ , Hiorns MP , et al.   Drug-induced lung disease (High-resolution CT and histological findings) . Clin Radiol . 2002;57:292–299
  5. Foucher P, Camus P: http//www.pneumotox.com. Accessed July 28, 2005
  6. Myers J . Pathology of drug-induced lung disease . In:  Katzenstein A ,  Askin F editor. Surgical Pathology of Nonneoplastic Lung Disease . Philadelphia: WB Saunders; 1997;p. 81–111
  7. Myers JL , Limper AH , Swensen SJ . Drug-induced lung disease (A pragmatic classification incorporating HRCT appearances) . Semin Respir Crit Care Med . 2003;24:445–453
  8. Fraser RS , Müller NL , Colman N , et al.   Complications of therapeutic, biopsy, and monitoring procedures . In: Diagnosis of Diseases of the Chest . Philadelphia: WB Saunders; 1999;p. 2659–2695
  9. Erasmus JJ , McAdams HP , Rossi SE . Drug-induced lung injury . Semin Roentgenol . 2002;37:72–81
  10. Pietra GG . Pathologic mechanisms of drug-induced lung disorders . J Thorac Imaging . 1991;6:1–7
  11. Rosenow EC , Myers J , Swensen SJ , et al.   Drug-induced pulmonary disease (An update) . Chest . 1992;102:239–250
  12. Travis WD , Colby TV , Koss MN , et al.   Drug and radiation reactions . In:  King DW editors. Atlas of Nontumor Pathology. Non-neoplastic Disorders of the Lower Respiratory Tract . Washington, DC: American Registry of Patholoy and the Armed Forces Institute of Pathology; 2002;p. 321–350
  13. Zitnik RJ , Matthay RA . Drug-induced lung disease . In:  Schwarz MI ,  King TEJ editor. Interstitial Lung Disease . 3rd ed.. Hamilton, ON: BC Decker; 1998;p. 423–450
  14. Ellis SJ , Cleverley JR , Müller NL . Drug-induced lung disease (High-resolution CT findings) . AJR Am J Roentgenol . 2000;175:1019–1024
  15. Padley SPG , Adler B , Hansell DM , et al.   High-resolution computed tomography of drug-induced lung disease . Clin Radiol . 1992;46:232–236
  16. Kuhlman JE . The role of chest computed tomography in the diagnosis of drug-related reactions . J Thorac Imaging . 1991;6:52–61
  17. Dodd JD, Lee KS, Johkoh T, et al: Drug-induced bronchiolitis obliterans organizing pneumonia (BOOP): high-resolution CT findings in 10 patients. J Comput Assist Tomogr (in press)
  18. Souza CA , Müller NL , Johkoh T , et al.   Drug-induced eosinophilic pneumonia (high-resolution CT findings in 14 patients) . AJR Am J Roentgenol . 2006;186:368–373
  19. Müller NL , White DA , Jiang H , et al.   Diagnosis and management of drug-associated interstitial lung disease . Br J Cancer . 2004;91(suppl 2):24–30
  20. Katzenstein AL , Bloor CM , Leibow AA . Diffuse alveolar damage—The role of oxygen, shock, and related factors. A review . Am J Pathol . 1976;85:209–228
  21. Rossi SE , Erasmus JJ , McAdams HP , et al.   Pulmonary drug toxicity (Radiologic and pathologic manifestations) . Radiographics . 2000;20:1245–1259
  22. Desai SR , Wells AU , Rubens MB , et al.   Acute respiratory distress syndrome (CT abnormalities at long-term follow-up) . Radiology . 1999;210:29–35
  23. Wong P , Leung AN , Berry GJ , et al.   Paclitaxel-induced hypersensitivity pneumonitis (Radiographic and CT findings) . AJR Am J Roentgenol . 2001;176:718–720
  24. Sossai P , Cappellato MG , Stefani S . Can a drug-induced pulmonary hypersensitivity reaction be dose-dependent? A case with mesalamine . Mt Sinai J Med . 2001;68:389–395
  25. Wong P , Leung AN , Berry GJ , et al.   Paclitaxel-induced hypersensitivity pneumonitis (Radiographic and CT findings) . AJR Am J Roentgenol . 2001;176:718–720
  26. Bourke SJ , Dalphin JC , Boyd G , et al.   Hypersensitivity pneumonitis (Current concepts) . Eur Respir J . 2001;32(suppl):81S–92S
  27. MacDonald SL , Rubens MB , Hansell DM , et al.   Nonspecific interstitial pneumonia and usual interstitial pneumonia (Comparative appearances at and diagnostic accuracy of thin-section CT) . Radiology . 2001;221:600–605
  28. American Thoracic Society/European Respiratory Society International Multidisciplinary Consensus Classification of the Idiopathic Interstitial Pneumonias . Am J Respir Crit Care Med . 2002;165:277–304
  29. Lynch DA , Travis WD , Müller NL , et al.   Idiopathic interstitial pneumonias (CT features) . Radiology . 2005;236:10–21
  30. Hartman TE , Swensen SJ , Hansell DM , et al.   Nonspecific interstitial pneumonia (Variable appearance at high-resolution chest CT) . Radiology . 2000;217:701–705
  31. Romero S , Martin C , Massuti B , et al.   Malignant lymphoma in a patient with relapsing bronchiolitis obliterans organizing pneumonia . Chest . 1992;102:1895–1897
  32. Thirman MJ , Devine SM , O’Toole K , et al.   Bronchiolitis obliterans organizing pneumonia as a complication of allogeneic bone marrow transplantation . Bone Marrow Transplant . 1992;10:307–311
  33. Bayle JY , Nesme P , Bejui-Thivolet F , et al.   Migratory organizing pneumonitis “primed” by radiation therapy . Eur Respir J . 1995;8:322–326
  34. Camus P , Colby TV . The lung in inflammatory bowel disease . Eur Respir J . 2000;15:5–10
  35. Camus P , Piard F , Ashcroft T , et al.   The lung in inflammatory bowel disease . Medicine (Baltimore) . 1993;72:151–183
  36. Khater FJ , Moorman JP , Myers JW , et al.   Bronchiolitis obliterans organizing pneumonia as a manifestation of AIDS (Case report and literature review) . J Infect . 2004;49:159–164
  37. Allen JN , Wewers MD . HIV-associated bronchiolitis obliterans organizing pneumonia . Chest . 1989;96:197–198
  38. Allen JN , Pacht ER , Gadek JE , et al.   Acute eosinophilic pneumonia as a reversible cause of noninfectious respiratory failure . N Engl J Med . 1989;321:569–574
  39. Epler GR . Drug-induced bronchiolitis obliterans organizing pneumonia . Clin Chest Med . 2004;25:89–94
  40. Haralambou G , Teirstein AS , Gil J , et al.   Bronchiolitis obliterand in a patient with ulcerative colitis receiving mesalamine . Mt Sinai J Med . 2001;68:384–389
  41. Arakawa H , Kurihara Y , Niimi H , et al.   Bronchiolitis obliterans with organizing pneumonia versus chronic eosinophilic pneumonia (High-resolution CT findings in 81 patients) . AJR Am J Roentgenol . 2001;176:1053–1058
  42. Lee JS , Lynch DA , Sharma S , et al.   Organizing pneumonia (prognostic implication of high-resolution computed tomography features) . J Comput Assist Tomogr . 2003;27:260–265
  43. Santrach PJ , Askin FB , Wells RJ , et al.   Nodular form of bleomycin-related pulmonary injury in patients with osteogenic sarcoma . Cancer . 1989;64:806–811
  44. Cohen MB , Austin JH , Smith-Vaniz A , et al.   Nodular bleomycin toxicity . Am J Clin Pathol . 1989;92:101–104
  45. Milesi-Lecat AM , Schmidt J , Aumaitre O , et al.   Lupus and pulmonary nodules consistent with bronchiolitis obliterans organizing pneumonia induced by carbamazepine . Mayo Clin Proc . 1997;72:1145–1147
  46. Banka R , Ward MJ . Bronchiolitis obliterans and organising pneumonia caused by carbamazepine and mimicking community acquired pneumonia . Postgrad Med J . 2002;78:621–622
  47. Camus P , Kudoh S , Ebina M . Interstitial lung disease associated with drug therapy . Br J Cancer . 2004;91(suppl):18–23
  48. Allen JN , Davis WB . Eosinophilic lung diseases . Am J Respir Crit Care Med . 1994;150:1423–1438
  49. Saltzman K , Rossof LJ , Gouda H , et al.   Mesalamine-induced unilateral eosinophilic pneumonia . AJR Am J Roentgenol . 2001;177:257
  50. Bain GA , Flower CD . Pulmonary eosinophilia . Eur J Radiol . 1996;23:3–8
  51. Silva CI , Müller NL , Fujimoto K , et al.   Churg-Strauss syndrome (High-resolution CT and pathologic findings) . J Thorac Imaging . 2005;20:74–80
  52. Cooper JA , White DA , Matthay RA . Drug induced pulmonary disease: Part 1. Cytoxic drugs . Am Rev Respir Dis . 1986;133:321–340
  53. Cooper JA , White DA , Matthay RA . Drug induced pulmonary disease: Part 2. Noncytoxic drugs . Am Rev Respir Dis . 1986;133:488–503
  54. Kim Y , Lee KS , Choi DC , et al.   The spectrum of eosinophilic lung disease (Radiologic findings) . J Comput Assist Tomogr . 1997;21:920–930
  55. Johkoh T , Müller NL , Akira M , et al.   Eosinophilic lung diseases (Diagnostic accuracy of thin-section CT in 111 patients) . Radiology . 2000;216:773–780

PII: S0887-2171(06)00002-3

doi: 10.1053/j.sult.2006.01.001

Seminars in Ultrasound, CT and MRI
Volume 27, Issue 2 , Pages 111-116 , April 2006