Seminars in Ultrasound, CT and MRI
Volume 27, Issue 1 , Pages 2-10 , February 2006

MRI of Myocardial Perfusion

  • Michael Jerosch-Herold, PhD

      Affiliations

    • Advanced Imaging Research Center and Department of Medicine, Oregon Health & Science University, Portland, OR.
    • Corresponding Author InformationAddress reprint requests to Michael Jerosch-Herold, PhD, Advanced Imaging Research Center, MS L452, 3181 SW Sam Jackson Park Road, Portland, OR 97239.
    • ,
  • Olaf Muehling, MD

      Affiliations

    • Department of Medicine, University of Munich, Munich, Germany.
    • ,
  • Norbert Wilke, MD

      Affiliations

    • Department of Radiology, Health Science Center, University of Florida, Jacksonville, FL.

References 

  1. Shaw LJ , Hachamovitch R , Heller GV , et al.  The Economics of Noninvasive Diagnosis (END) Study Group   Noninvasive strategies for the estimation of cardiac risk in stable chest pain patients . Am J Cardiol . 2000;86:1–7
  2. Shaw LJ , Hendel R , Borges-Neto S , et al.   Prognostic value of normal exercise and adenosine (99m)Tc-tetrofosmin SPECT imaging (Results from the multicenter registry of 4,728 patients) . J Nucl Med . 2003;44:134–139
  3. Hachamovitch R , Hayes SW , Friedman JD , et al.   A prognostic score for prediction of cardiac mortality risk after adenosine stress myocardial perfusion scintigraphy . J Am Coll Cardiol . 2005;45:722–729
  4. Berman DS , Kiat H , Friedman JD , et al.   Clinical applications of exercise nuclear cardiology studies in the era of healthcare reform . Am J Cardiol . 1995;75:3D–13D
  5. Hachamovitch R , Hayes SW , Friedman JD , et al.   Comparison of the short-term survival benefit associated with revascularization compared with medical therapy in patients with no prior coronary artery disease undergoing stress myocardial perfusion single photon emission computed tomography . Circulation . 2003;107:2900–2907
  6. Berman DS , Hachamovitch R . Risk assessment in patients with stable coronary artery disease (Incremental value of nuclear imaging) . J Nucl Cardiol . 1996;3(6 Pt 2):S41–S49
  7. Wagner A , Mahrholdt H , Holly TA , et al.   Contrast-enhanced MRI and routine single photon emission computed tomography (SPECT) perfusion imaging for detection of subendocardial myocardial infarcts (An imaging study) . Lancet . 2003;361:374–379
  8. Debatin JF , Nadel SN , Paolini JF , et al.   Cardiac ejection fraction (phantom study comparing cine MR imaging, radionuclide blood pool imaging, and ventriculography) . J Magn Reson Imaging . 1992;2:135–142
  9. Reichek N . Cardiac magnetic resonance imaging and core cardiology training II (COCATS-2) (can we get there from here?) . J Am Coll Cardiol . 2004;43:2113–2115
  10. Wilson RF , Marcus ML , White CW . Prediction of the physiologic significance of coronary arterial lesions by quantitative lesion geometry in patients with limited coronary artery disease . Circulation . 1987;75:723–732
  11. Uren NG , Melin JA , De Bruyne B , et al.   Relation between myocardial blood flow and the severity of coronary-artery stenosis . N Engl J Med . 1994;330:1782–1788
  12. Hoffman JI . Heterogeneity of myocardial blood flow . Basic Res Cardiol . 1995;90:103–111
  13. Canty JM , Klocke FJ . Reductions in regional myocardial function at rest in conscious dogs with chronically reduced regional coronary artery pressure . Circ Res . 1987;61(5 Pt 2):II107–II116
  14. Laxson DD , Dai XZ , Homans DC , et al.   Coronary vasodilator reserve in ischemic myocardium of the exercising dog . Circulation . 1992;85:313–322
  15. Cannon RO , Schenke WH , Quyyumi A , et al.   Comparison of exercise testing with studies of coronary flow reserve in patients with microvascular angina . Circulation . 1991;83(5 Suppl):III77–III81
  16. Pepine CJ , Balaban RS , Bonow RO , et al.   Women’s ischemic syndrome evaluation: Current status and future research directions: Report of the National Heart, Lung and Blood Institute workshop, October 2-4, 2002: Section 1: Diagnosis of stable ischemia and ischemic heart disease . Circulation . 2004;109:e44–e46
  17. Doyle M , Fuisz A , Kortright E , et al.   The impact of myocardial flow reserve on the detection of coronary artery disease by perfusion imaging methods (An NHLBI WISE study) . J Cardiovasc Magn Reson . 2003;5:475–485
  18. Panting JR , Gatehouse PD , Yang GZ , et al.   Abnormal subendocardial perfusion in cardiac syndrome X detected by cardiovascular magnetic resonance imaging . N Engl J Med . 2002;346:1948–1953
  19. Wilke N , Jerosch-Herold M , Wang Y , et al.   Myocardial perfusion reserve (Assessment with multisection, quantitative, first-pass MR imaging) . Radiology . 1997;204:373–384
  20. Shelton ME , Senneff MJ , Ludbrook PA , et al.   Concordance of nutritive myocardial perfusion reserve and flow velocity reserve in conductance vessels in patients with chest pain with angiographically normal coronary arteries . J Nucl Med . 1993;34:717–722
  21. Buchthal SD , den Hollander JA , Merz CN , et al.   Abnormal myocardial phosphorus-31 nuclear magnetic resonance spectroscopy in women with chest pain but normal coronary angiograms . N Engl J Med . 2000;342:829–835
  22. Wu KC , Kim RJ , Bluemke DA , et al.   Quantification and time course of microvascular obstruction by contrast-enhanced echocardiography and magnetic resonance imaging following acute myocardial infarction and reperfusion . J Am Coll Cardiol . 1998;32:1756–1764
  23. Rochitte CE , Lima JA , Bluemke DA , et al.   Magnitude and time course of microvascular obstruction and tissue injury after acute myocardial infarction . Circulation . 1998;98:1006–1014
  24. Wu KC , Zerhouni EA , Judd RM , et al.   Prognostic significance of microvascular obstruction by magnetic resonance imaging in patients with acute myocardial infarction . Circulation . 1998;97:765–772
  25. Gerber BL , Rochitte CE , Melin JA , et al.   Microvascular obstruction and left ventricular remodeling early after acute myocardial infarction . Circulation . 2000;101:2734–2741
  26. Hombach V , Grebe O , Merkle N , et al.   Sequelae of acute myocardial infarction regarding cardiac structure and function and their prognostic significance as assessed by magnetic resonance imaging . Eur Heart J . 2005;26:549–557
  27. Lund GK , Stork A , Saeed M , et al.   Acute myocardial infarction (evaluation with first-pass enhancement and delayed enhancement MR imaging compared with 201Tl SPECT imaging) . Radiology . 2004;232:49–57
  28. Jerosch-Herold M , Hu X , Murthy NS , et al.   Time delay for arrival of MR contrast agent in collateral-dependent myocardium . IEEE Trans Med Imaging . 2004;23:881–890
  29. Heusch G , Schulz R , Rahimtoola SH . Myocardial hibernation (A delicate balance) . Am J Physiol Heart Circ Physiol . 2005;288:H984–H999
  30. Bolli R , Zhu W-X , Thornby JI , et al.   Time course and determinants of recovery of function after reversible ischemia in conscious dogs . Am J Physiol . 1988;254:H102–H114
  31. Selvanayagam J , Jerosch-Herold M , Porto I , et al.   Resting myocardial blood flow is impaired in hibernating myocardium (An MR study of quantitative perfusion assessment) . Circulation . 2005;112:3289–3296
  32. Kwong RY , Schussheim AE , Rekhraj S , et al.   Detecting acute coronary syndrome in the emergency department with cardiac magnetic resonance imaging . Circulation . 2003;107:531–537
  33. Plein S , Greenwood JP , Ridgway JP , et al.   Assessment of non-ST-segment elevation acute coronary syndromes with cardiac magnetic resonance imaging . J Am Coll Cardiol . 2004;44:2173–2181
  34. Sipola P , Lauerma K , Husso-Saastamoinen M , et al.   First-pass MR imaging in the assessment of perfusion impairment in patients with hypertrophic cardiomyopathy and the Asp175Asn mutation of the {alpha}-tropomyosin gene . Radiology . 2003;226:129–137
  35. Kawada N , Sakuma H , Yamakado T , et al.   Hypertrophic cardiomyopathy (MR measurement of coronary blood flow and vasodilator flow reserve in patients and healthy subjects) . Radiology . 1999;211:129–135
  36. McCrohon JA , Moon JC , Prasad SK , et al.   Differentiation of heart failure related to dilated cardiomyopathy and coronary artery disease using gadolinium-enhanced cardiovascular magnetic resonance . Circulation . 2003;108:54–59
  37. Reeder SB , Atalar E , Faranesh AZ , et al.   Multi-echo segmented k-space imaging (An optimized hybrid sequence for ultrafast cardiac imaging) . Magn Reson Med . 1999;41:375–385
  38. Schreiber WG , Schmitt M , Kalden P , et al.   Dynamic contrast-enhanced myocardial perfusion imaging using saturation-prepared TrueFISP . J Magn Reson Imaging . 2002;16:641–652
  39. Nitz WR . Fast and ultrafast non-echo-planar MR imaging techniques . Eur Radiol . 2002;12:2866–2882
  40. Hunold P , Maderwald S , Eggebrecht H , et al.   Steady-state free precession sequences in myocardial first-pass perfusion MR imaging (Comparison with TurboFLASH imaging) . Eur Radiol . 2004;14:409–416
  41. Klocke FJ , Simonetti OP , Judd RM , et al.   Limits of detection of regional differences in vasodilated flow in viable myocardium by first-pass magnetic resonance perfusion imaging . Circulation . 2001;104:2412–2416
  42. Tsekos NV , Zhang Y , Merkle H , et al.   Fast anatomical imaging of the heart and assessment of myocardial perfusion with arrhythmia insensitive magnetization preparation . Magn Reson Med . 1995;34:530–536
  43. Bianco JA , Alpert JS . Physiologic and clinical significance of myocardial blood flow quantitation (What is expected from these measurements in the clinical ward and in the physiology laboratory?) . Cardiology . 1997;88:116–126
  44. Zierler KL . Equations for measuring blood flow by external monitoring of radioisotopes . Circ Res . 1965;16:309–321
  45. Jerosch-Herold M , Seethamraju RT , Swingen CM , et al.   Analysis of myocardial perfusion MRI . J Magn Reson Imaging . 2004;19:758–770
  46. Jerosch-Herold M , Swingen C , Seethamraju RT . Myocardial blood flow quantification with MRI by model-independent deconvolution . Med Phys . 2002;29:886–897
  47. Matheijssen NA , Louwerenburg HW , van Rugge FP , et al.   Comparison of ultrafast dipyridamole magnetic resonance imaging with dipyridamole SestaMIBI SPECT for detection of perfusion abnormalities in patients with one-vessel coronary artery disease (Assessment by quantitative model fitting) . Magn Reson Med . 1996;35:221–228
  48. Keijer JT , van Rossum AC , Wilke N , et al.   Magnetic resonance imaging of myocardial perfusion in single-vessel coronary artery disease (Implications for transmural assessment of myocardial perfusion) . J Cardiovasc Magn Reson . 2000;2:189–200
  49. Al-Saadi N , Nagel E , Gross M , et al.   Noninvasive detection of myocardial ischemia from perfusion reserve based on cardiovascular magnetic resonance . Circulation . 2000;101:1379–1383
  50. Christian TF , Rettmann DW , Aletras AH , et al.   Absolute myocardial perfusion in canines measured by using dual-bolus first-pass MR imaging . Radiology . 2004;232:677–684
  51. Jerosch-Herold M , Hu X , Murthy NS , et al.   MRI of myocardial contrast enhancement with MS-325 and its relation to myocardial blood flow and the perfusion reserve . J Magn Reson Imaging . 2003;18:544–554
  52. Kroll K , Wilke N , Jerosch-Herold M , et al.   Accuracy of modeling of regional myocardial flows from residue functions of an intravascular indicator . Am J Physiol (Heart Circ Physiol) . 1996;40:H1643–H1655
  53. Wilke N , Kroll K , Merkle H , et al.   Regional myocardial blood volume and flow (First-pass MR imaging with polylysine-Gd-DTPA) . J Magn Reson Imaging . 1995;5:227–237
  54. Ibrahim T , Nekolla SG , Schreiber K , et al.   Assessment of coronary flow reserve (Comparison between contrast- enhanced magnetic resonance imaging and positron emission tomography) . J Am Coll Cardiol . 2002;39:864–870
  55. Schwitter J , Nanz D , Kneifel S , et al.   Assessment of myocardial perfusion in coronary artery disease by magnetic resonance (A comparison with positron emission tomography and coronary angiography) . Circulation . 2001;103:2230–2235
  56. Muehling O , Panse P , Jerosch-Herold M , et al.   Cardiac magnetic resonance perfusion imaging identifies transplant arteriopathy by a reduced endomyocardial resting perfusion . J Heart Lung Transplant . 2005;24:1122–1123
  57. Mühling OM , Jerosch-Herold M , Panse P , et al.   Regional heterogeneity of myocardial perfusion in healthy human myocardium (Assessment with magnetic resonance perfusion imaging) . J Cardiovasc Magn Reson . 2004;6:499–507
  58. Mühling OM , Wilke NM , Panse P , et al.   Transmural myocardial perfusion in transplanted human hearts assessed by magnetic resonance imaging . J Am Coll Cardiol . 2003;42:1054–1060
  59. Nagel E , Klein C , Paetsch I , et al.   Magnetic resonance perfusion measurements for the noninvasive detection of coronary artery disease . Circulation . 2003;108:432–437
  60. Al-Saadi N , Nagel E , Gross M , et al.   Improvement of myocardial perfusion reserve early after coronary intervention (Assessment with cardiac magnetic resonance imaging) . J Am Coll Cardiol . 2000;36:1557–1564
  61. Giang TH , Nanz D , Coulden R , et al.   Detection of coronary artery disease by magnetic resonance myocardial perfusion imaging with various contrast medium doses (First European multi-centre experience) . Eur Heart J . 2004;25:1657–1665

PII: S0887-2171(05)00080-6

doi: 10.1053/j.sult.2005.10.001

Seminars in Ultrasound, CT and MRI
Volume 27, Issue 1 , Pages 2-10 , February 2006

Article Tools

* Image Usage & Resolution